Benzoyl isothiocyanate → HCID 57813664, compound

HRID 447013Notes

Reaction equation

HRID 447013 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:13])[CH:5]=[C:6]([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)[CH:7]=1.[C:14]([N:22]=[C:23]=[S:24])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CC(C)=O>[C:14]([NH:22][C:23]([NH:13][C:4]1[CH:5]=[C:6]([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)[CH:7]=[C:2]([Br:1])[CH:3]=1)=[S:24])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 68284Benzoyl isothiocyanateHCID 57813693HCID 57813693, compound

Product 1

HCID 57813664HCID 57813664, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To the solution of 3-bromo-5-pyrazol-1-yl-phenylamine (0.18 g, 0.76 mmol) in anhydrous acetone (5.0 mL) was added benzoylisothiocyanate (0.14 g, 0.83 mmol) and the reaction mixture was stirred at room temperature for 30 min. Acetone was distilled off and the crude residue was washed with hexane to obtain desired compound (0.27 g, 89%).

Workup

  1. distillationAcetone was distilled off
  2. washthe crude residue was washed with hexane

Sources & evidence

ORD record
ord-e8721b286a024a8084f9887a42e97775
Source dataset
uspto-grants-2013_07
Patent number
US08481544B2

Reaction notes

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