Water → 2,6-Dibromopyridin-4-amine

Temperature

90 °C

To a solution of 2,6-dibromo-4-nitro-pyridine (1.0 g, 3.54 mmol) in glacial acetic acid (20 mL) was added Fe-powder (1.0 g, 17.74 mmol) at room temperature. The reaction mixture was refluxed for 90° C. for 30 min. After completion of reaction (TLC monitoring), water was added (100 mL), basified with 2N NaOH (pH 12-14). The resulting mixture was filtered through celite-bed and extracted with ethyl acetate (2×50 mL). The combined organic layers were washed with water, dried (Na2SO4), filtered and evaporated to dryness to get the desired product as an off white solid (0.80 g, 90%).

1. additionwas added (100 mL)
2. filtrationThe resulting mixture was filtered through celite-bed and
3. extractionextracted with ethyl acetate (2×50 mL)
4. washThe combined organic layers were washed with water
5. dry with materialdried (Na2SO4)
6. filtrationfiltered
7. customevaporated to dryness

ORD record

ord-1b684158232742d3bd98bb0143e665d6

Source dataset

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08481544B2