反应详情

温度

70 °C

To a solution of (R)-2-methyl-4-boc-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl-5′-carboxylic acid methyl ester (2 g, 5.94 mmol) in MeOH (17 mL) is added HCl (4M in dioxane, 4.5 mL, 18 mmol). The reaction mixture is stirred at 70° C. for 1 h. The reaction solution is concentrated, dissolved in DCM and organic layer is washed with Na2CO3 to adjust the pH value to 8.0. The solvents are removed under reduced pressure to afford a brown oil (1.2 g, 77%).

1. concentrationThe reaction solution is concentrated
2. dissolutiondissolved in DCM
3. washorganic layer is washed with Na2CO3
4. customThe solvents are removed under reduced pressure