反应详情

温度

-30 °C

2-Methyl-pyridine (1.86 g, 20 mmol) is dissolved in THF (20 mL) and cooled to −30° C. tert-Butyl lithium (11.8 mL, 1.7M in pentane, 20 mmol) is added dropwise to the solution, and the reaction is stirred for 30 min at −30° C. 2,4-Dimethyl-pentan-3-one (3.4 mL, 24 mmol) is added and the reaction is warmed to room temperature and stirred for 2 h. Add H2O (30 mL) and extract with EtOAc. Wash combined organics with brine and concentrate in vacuo. The residue is purified by flash chromatography on silica gel (EtOAc/Heptane) to afford 2,4-dimethyl-3-pyridin-2-ylmethyl-pentan-3-ol (4.14 g, quant.).

1. additionis added dropwise to the solution
2. temperaturethe reaction is warmed to room temperature
3. stirringstirred for 2 h
4. extractionAdd H2O (30 mL) and extract with EtOAc
5. washWash
6. concentrationconcentrate in vacuo
7. customThe residue is purified by flash chromatography on silica gel (EtOAc/Heptane)