Hydrochloric Acid → (S)-2-amino-N-(2-(benzo[d]oxazol-2-ylamino)ethyl)pent-4-ynamide hydrochloride

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Reaction Steps

(S)-tert-Butyl 1-(2-(benzo[d]oxazol-2-ylamino)ethylamino)-1-oxopent-4-yn-2-ylcarbamate (99.5 mg, 0.267 mmol) was dissolved in 1,4-dioxane (3.5 mL) and treated with 4N HCl in 1,4-dioxane (3.5 mL). The resulting mixture was stirred for 2.5 h and a solid separated from the solution. HCl in 1,4-dioxane (1 mL) was added and the resulting mixture was stirred for 3 h. The solid product was collected by filtration, washed with 1,4-dioxane, then dried in vacuum oven for 1 day at room temperature to yield the title compound as its corresponding hydrochloride salt, as a white solid.

Provenance & Evidence