反应详情

(S)-tert-Butyl 1-(2-(benzo[d]oxazol-2-ylamino)ethylamino)-1-oxopent-4-yn-2-ylcarbamate (99.5 mg, 0.267 mmol) was dissolved in 1,4-dioxane (3.5 mL) and treated with 4N HCl in 1,4-dioxane (3.5 mL). The resulting mixture was stirred for 2.5 h and a solid separated from the solution. HCl in 1,4-dioxane (1 mL) was added and the resulting mixture was stirred for 3 h. The solid product was collected by filtration, washed with 1,4-dioxane, then dried in vacuum oven for 1 day at room temperature to yield the title compound as its corresponding hydrochloride salt, as a white solid.

1. customa solid separated from the solution
2. additionHCl in 1,4-dioxane (1 mL) was added
3. stirringthe resulting mixture was stirred for 3 h
4. filtrationThe solid product was collected by filtration
5. washwashed with 1,4-dioxane
6. customdried in vacuum oven for 1 day at room temperature