反应详情

tert-Butyl 2-(6-(3,4-dimethoxyphenylcarbamoyl)benzo[d]thiazol-2-ylamino)ethyl(methyl)carbamate (327.1 mg, 0.672 mmol) was dissolved in 1,4-dioxane (4 mL) and then treated with 4N HCl in 1,4-dioxane (4 mL, 16.0 mmol). The resulting mixture was stirred for 2 h and a solid separated from the solution. The solid was collected by filtration, washed with 1,4-dioxane, then dried in vacuum oven for 2 d at room temperature to yield the hydrochloride salt of N-(3,4-dimethoxyphenyl)-2-(2-(methylamino)ethylamino)benzo[d]thiazole-6-carboxamide as a yellow solid.

1. customa solid separated from the solution
2. filtrationThe solid was collected by filtration
3. washwashed with 1,4-dioxane
4. customdried in vacuum oven for 2 d at room temperature