反应详情

(S)-tert-butyl 1-(4-(benzo[d]oxazol-2-yl)piperazin-1-yl)-1-oxo-3-(thiophen-2-yl)propan-2-ylcarbamate (367.5 mg, 0.805 mmol) was dissolved in 1,4-dioxane (5 mL) and treated with 4N hydrogen chloride in 1,4-dioxane (5 mL, 12.0 mmol). The resulting mixture was stirred at room temperature for 3 h, then additional 4N HCl in 1,4-dioxane (1 mL) was added and the resulting mixture stirred for 18 h. The resulting solid was collected by decantation, washed with 1,4-dioxane, and purified by recrystallization from an isopropanol-diethyl ether mixture to yield the title compound as an off-white solid.

1. stirringthe resulting mixture stirred for 18 h
2. customThe resulting solid was collected by decantation
3. washwashed with 1,4-dioxane
4. custompurified by recrystallization from an isopropanol-diethyl ether mixture