HCID 67236011, compound → (2-(Piperazin-1-yl)benzo[d]thiazol-6-yl)methanol

HRID 447164Notes

Reaction equation

HRID 447164 reaction equation
[OH:1][CH2:2][C:3]1[CH:24]=[CH:23][C:6]2[N:7]=[C:8]([N:10]3[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]3)[S:9][C:5]=2[CH:4]=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[N:10]1([C:8]2[S:9][C:5]3[CH:4]=[C:3]([CH2:2][OH:1])[CH:24]=[CH:23][C:6]=3[N:7]=2)[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1

Participants

4

Reactant 1

HCID 67236011HCID 67236011, compound

Product 1

HCID 67235770(2-(Piperazin-1-yl)benzo[d]thiazol-6-yl)methanolYield 98.1%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

The tert-butyl 4-(6-(hydroxymethyl)benzo[d]thiazol-2-yl)piperazine-1-carboxylate (1.0 g) was dissolved in a mixture of TFA (2 mL) and DCM (20 mL) and stirred at room temperature. After four hours, the resulting mixture was concentrated to yield (2-(piperazin-1-yl)benzo[d]thiazol-6-yl)methanol as a yellow oil (0.7 g). MS: 250.3 (M+H).

Workup

  1. concentrationthe resulting mixture was concentrated

Sources & evidence

ORD record
ord-ee9e5d4a29404f24b9f33656cbd2cf97
Source dataset
uspto-grants-2013_07
Patent number
US08481547B2

Reaction notes

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