(4-Fluoro-3-methylphenyl)boronic acid → 2-Chloro-4-[1-(4-fluoro-3-methyl-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine

HRID 447196Notes

Reaction equation

HRID 447196 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.[F:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][C:18]=1[CH3:26]>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[N:13]([C:20]3[CH:21]=[CH:22][C:17]([F:16])=[C:18]([CH3:26])[CH:19]=3)[CH:14]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 2774580(4-Fluoro-3-methylphenyl)boronic acidHCID 178418879HCID 178418879, compound

Product 1

HCID 865953162-Chloro-4-[1-(4-fluoro-3-methyl-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine

Procedure

The title compound, MS: m/e=326.4 (M+H+), was prepared in accordance with the general method of example 7 from 2-chloro-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 4-fluoro-3-methyl-benzene boronic acid.

Sources & evidence

ORD record
ord-c73591c8297e4ebeab774438d676f800
Source dataset
uspto-grants-2013_07
Patent number
US08481548B2

Reaction notes

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