反应详情

A mixture of 1-aminocyclohexanecarbonitrile (48.5 g, 391 mmol) and platinum oxide (5.0 g) in 4.2 M HCl in ethanol (200 mL) and 2.7 M HCl in ethanol (300 mL) was hydrogenated at 50 psi (3.4×105 Pa) for 20 h on a Parr apparatus. The reaction mixture was filtered through CELITE filter agent and the filtrate was concentrated to yield a clear oil. The oil was triturated with isopropanol to yield a white solid that was isolated by filtration, washed with ether, and dried to provide 1-(aminomethyl)cyclohexanamine dihydrochloride (70.0 g, 89%).

1. filtrationThe reaction mixture was filtered through CELITE
2. filtrationfilter agent
3. concentrationthe filtrate was concentrated
4. customto yield a clear oil
5. customThe oil was triturated with isopropanol
6. customto yield a white solid
7. customthat was isolated by filtration
8. washwashed with ether
9. customdried