HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 447769Generated: October 29, 2026
Potassium Carbonate → 2,3-Difluoro-1-methyl-4-nitrobenzene
https://huagongshe.com/reaction/447769
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (2,3-Difluoro-6-nitrophenyl)acetic acid | HCID 22475350 | — |
| Reactant | 1,2-Difluoro-3-methyl-4-nitrobenzene | HCID 46941303 | — |
| Reactant | HCID 53411782 | HCID 53411782 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2,3-Difluoro-1-methyl-4-nitrobenzene | HCID 58785225 | — |
Reaction Steps
The mixture of 2,3-difluoro-4-nitrophenylacetic acid and 2,3-difluoro-6-nitrophenylacetic acid from D16 (13.5 g) was dissolved in dimethylformamide (100 ml) and potassium carbonate (8.5 g) added. After stirring at 50° C. for 30 min the cooled solution was partitioned between aqueous hydrochloric acid and hexane. Drying (MgSO4), evaporation, and chromatography (0-5% ethyl acetate in hexane, 70 g silica column) gave 3.2 g of a 3:1 mixture of the title compound and 2,3-difluoro-6-nitrotoluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08481566B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-29e16d5b73044fad9e91932972fb2228 |
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| Source note | uspto-grants-2013_07 |
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