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HRID447769

反应详情

EQUATION

反应方程式

HRID 447769 的结构方程式

REACTANTS

反应物

4
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：O=C(O)Cc1c([N+](=O)[O-])ccc(F)c1F
HCID22475350

(2,3-Difluoro-6-nitrophenyl)acetic acid

C8H5F2NO4

结构：Cc1c([N+](=O)[O-])ccc(F)c1F
HCID46941303

1,2-Difluoro-3-methyl-4-nitrobenzene

C7H5F2NO2

结构：O=C(O)Cc1ccc([N+](=O)[O-])c(F)c1F
HCID53411782

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc([N+](=O)[O-])c(F)c1F
HCID58785225

2,3-Difluoro-1-methyl-4-nitrobenzene

C7H5F2NO2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
50 °C

PROCEDURE

实验过程

The mixture of 2,3-difluoro-4-nitrophenylacetic acid and 2,3-difluoro-6-nitrophenylacetic acid from D16 (13.5 g) was dissolved in dimethylformamide (100 ml) and potassium carbonate (8.5 g) added. After stirring at 50° C. for 30 min the cooled solution was partitioned between aqueous hydrochloric acid and hexane. Drying (MgSO4), evaporation, and chromatography (0-5% ethyl acetate in hexane, 70 g silica column) gave 3.2 g of a 3:1 mixture of the title compound and 2,3-difluoro-6-nitrotoluene.

WORKUP

后处理

  1. customwas partitioned between aqueous hydrochloric acid and hexane
  2. customDrying
  3. custom(MgSO4), evaporation, and chromatography (0-5% ethyl acetate in hexane, 70 g silica column)
  4. customgave