反应详情

A mixture of (2-amino-3-fluoro-5-methylphenyl)[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]amine (0.5 g), N,N′-carbonyldiimidazole (0.66 g) and tetrahydrofuran (7 ml) was heated to reflux. After 30 minutes, tetrahydrofuran (3 ml) was added, and the mixture heated at reflux for a further 1½ hours. The reaction mixture was filtered and washed with tetrahydrofuran (10 ml), then the solid was dried at 40-45° C. under high vacuum to give the title compound (0.323 g).

1. temperaturewas heated to reflux
2. temperaturethe mixture heated
3. temperatureat reflux for a further 1½ hours
4. filtrationThe reaction mixture was filtered
5. washwashed with tetrahydrofuran (10 ml)
6. customthe solid was dried at 40-45° C. under high vacuum