反应详情

(Step 2) To a solution of N-[5-chloro-2-(dimethylsulfamoyl)benzyl]acetamide obtained in Step 1 (1.77% g) in ethanol (20 ml) was added 6N hydrochloric acid (20 ml) at room temperature. The mixture was stirred with heating under reflux for 3 hr, and then stirred overnight at 80° C. The solvent was evaporated under reduced pressure. The residue was collected by filtration, and washed with diethyl ether to give 2-(aminomethyl)-4-chloro-N,N-dimethylbenzenesulfonamide hydrochloride (1.61 g) as a white solid.

1. temperaturewith heating
2. temperatureunder reflux for 3 hr
3. stirringstirred overnight at 80° C
4. customThe solvent was evaporated under reduced pressure
5. filtrationThe residue was collected by filtration
6. washwashed with diethyl ether