反应详情

Palladium hydroxide (2.3 g of 20% on carbon) was added to a solution of 1-methyl-4-nitromethylpiperidin-4-ol (11.57 g) in ethanol (120 mL). The mixture was placed under hydrogen pressure (50 psi, 3.4×105 Pa) on a Parr apparatus for 55 hours. The reaction mixture was filtered through a layer of CELITE filter aid and the filter cake was rinsed with methanol (100 mL). The filtrate was concentrated under reduced pressure to provide 10.18 g of 4-aminomethyl-1-methylpiperidin-4-ol as a thick oil.

1. customfor 55 hours
2. filtrationThe reaction mixture was filtered through a layer of CELITE
3. filtrationfilter aid
4. washthe filter cake was rinsed with methanol (100 mL)
5. concentrationThe filtrate was concentrated under reduced pressure