反应详情

A mixture of 65 g (309.1 mmol) N-1,3-thiazole-2-yl-1H-imidazole-1-carbothioamide and 260 g of ammonium acetate were heated to 80° C. in 400 ml ethanol for 1.5 hours; after completion of reaction the solvent was distilled off and water was added to the obtained residue. After extraction with CH2Cl2 and drying of the organic phase with Na2SO4, 59.6 g of the target product were obtained.

1. customafter completion of reaction the solvent
2. distillationwas distilled off
3. additionwater was added to the obtained residue
4. extractionAfter extraction with CH2Cl2
5. dry with materialdrying of the organic phase with Na2SO4