反应详情

A suspension of 1-{[(3-nitroquinolin-4-yl)amino]methyl}cyclohexanol (15.0 g, 49.8 mmol) in ethyl acetate (225 mL) in a Parr vessel was purged with nitrogen; 5% platinum on carbon (1.5 g) was added. The reaction was placed under hydrogen pressure (35 psi, 2.4×105 Pa) for 3.5 hours and then filtered through a layer of CELITE filter agent. The filter cake was washed with ethyl acetate (100 mL), and the filtrate was concentrated under reduced pressure to provide 1-{[(3-aminoquinolin-4-yl)amino]methyl}cyclohexanol as a yellow solid.

1. customwas purged with nitrogen
2. addition5% platinum on carbon (1.5 g) was added
3. customfor 3.5 hours
4. filtrationfiltered through a layer of CELITE filter agent
5. washThe filter cake was washed with ethyl acetate (100 mL)
6. concentrationthe filtrate was concentrated under reduced pressure