反应详情

3.00 g (13.82 mmol) 2-bromo-4′-fluoroacetophenone, 2.80 g (27.64 mmol) acetylguanidine and 15 ml acetonitrile were combined and were together brought to reaction in the microwave (at 100 Watt) for 60 minutes at 40° C. by “heating by cooling”. After cooling, the solid formed was filtered off of the solvent. In addition, a total amount of 1.02 g N-[4-(4-fluorphenyl)-1H-imidazole-2-yl]acetamide were isolated by fractional crystallization with ethanol of the remainder of the mother liquor.

1. customwere together brought to reaction in the microwave (at 100 Watt) for 60 minutes at 40° C. by “
2. temperatureheating
3. temperatureby cooling”
4. temperatureAfter cooling
5. customthe solid formed
6. filtrationwas filtered off of the solvent