2-Bromo-1-(4-fluorophenyl)ethan-1-one → HCID 178474420, compound

Participants

Reaction Steps

3.00 g (13.82 mmol) 2-bromo-4′-fluoroacetophenone, 2.80 g (27.64 mmol) acetylguanidine and 15 ml acetonitrile were combined and were together brought to reaction in the microwave (at 100 Watt) for 60 minutes at 40° C. by “heating by cooling”. After cooling, the solid formed was filtered off of the solvent. In addition, a total amount of 1.02 g N-[4-(4-fluorphenyl)-1H-imidazole-2-yl]acetamide were isolated by fractional crystallization with ethanol of the remainder of the mother liquor.

Provenance & Evidence