Hydrochloric Acid → HCID 178479576, compound

HRID 447940Notes

Reaction equation

HRID 447940 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([NH:13]C(=O)C)[NH:11][CH:12]=2)=[CH:4][CH:3]=1.C(O)C.[ClH:20]>>[Cl-:20].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([NH3+:13])[NH:11][CH:12]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 178474420HCID 178474420, compound

Product 1

HCID 178479576HCID 178479576, compound

Procedure

1.0 g (4.56 mmol) N-[4-(4-fluorphenyl)-1H-imidazole-2-yl]acetamide were suspended in 30 ml 2 N HCl and 30 ml ethanol and were stirred at 80° C. for 2 hours. After removal of the solvent under vacuum, 0.97 g 4-(4-fluorphenyl)-1H-imid azole-2-aminium chloride were obtained, which was used in the following reaction without further purification.

Workup

  1. customAfter removal of the solvent under vacuum

Sources & evidence

ORD record
ord-fe0a78560c37467fb4a7fb8eb20d848c
Source dataset
uspto-grants-2013_07
Patent number
US08481576B2

Reaction notes

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