HCID 519042, compound → 1-(2-methylthiazol-5-yl)ethanone

HRID 448093Notes

Reaction equation

HRID 448093 reaction equation
Br[C:2](=[C:6]([OH:8])[CH3:7])[C:3](=O)C.[C:9]([NH2:12])(=[S:11])[CH3:10]>CC(C)=O>[C:6]([C:2]1[S:11][C:9]([CH3:10])=[N:12][CH:3]=1)(=[O:8])[CH3:7]

Participants

4

Reactant 2

HCID 519042HCID 519042, compoundHCID 2723949Thioacetamide

Product 1

HCID 208151861-(2-methylthiazol-5-yl)ethanone

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of the product of Example 151B (14.5 g, 88 mmol) in acetone (220 mL) was added thioacetamide (6.6 g, 88 mmol) and stirred overnight. The solid was filtered to give the title compound as the hydrogen bromide salt. 1H NMR (300 MHz, DMSO-d6) δ ppm 2.54 (s, 3 H) 2.71 (s, 3 H) 8.46 (s, 1 H). MS (DCI) m/z 142 (M+H)+.

Workup

  1. filtrationThe solid was filtered

Sources & evidence

ORD record
ord-7ce2d9ad574a4beea8cdfbe631fa4f0f
Source dataset
uspto-grants-2013_07
Patent number
US08481574B2

Reaction notes

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