Hydrochloric Acid → HCID 178480693, compound

HRID 448133Notes

Reaction equation

HRID 448133 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:31]=[CH:30][C:11]([C:12]([NH:14][C:15]3[C:16]4[CH:22]=[C:21]([C:23]([O:25]C(C)(C)C)=[O:24])[S:20][C:17]=4[NH:18][N:19]=3)=[O:13])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[ClH:32]>O1CCOCC1>[ClH:32].[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:9]=[CH:10][C:11]([C:12]([NH:14][C:15]3[C:16]4[CH:22]=[C:21]([C:23]([OH:25])=[O:24])[S:20][C:17]=4[NH:18][N:19]=3)=[O:13])=[CH:30][CH:31]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178480694HCID 178480694, compound

Product 1

HCID 178480693HCID 178480693, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of tert-butyl 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylate (0.50 g, 1.1 mmol) in hydrochloric acid 4M in dioxane (15 mL) was stirred for 16 hours at room temperature. Afterward, volatiles were removed by evaporation under reduced pressure and the residue was triturated with ethyl ether to give 0.496 g of the title compound as a white solid.

Workup

  1. customAfterward, volatiles were removed by evaporation under reduced pressure
  2. customthe residue was triturated with ethyl ether

Sources & evidence

ORD record
ord-6cef3cb316ed4f03a616d3cfc150478b
Source dataset
uspto-grants-2013_07
Patent number
US08481584B2

Reaction notes

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