反应详情

To a stirred solution of 3-(4-(Benzyloxy)-4-oxobutanoyl)phenyl 2,6-dimethylbenzoate (Step C, 2.75 g, 6.6 mmol) in ethyl acetate was added Pd—C (5%, 0.230 g) under an argon atmosphere. The starting material was hydrogenated under a H2 atm for 14 hours and filtered through a celite pad. The filtrate was concentrated and purified by flash chromatography on a silica gel column (chloroform:methanol, 92.5:7.5 spiked with acetic acid) to provide the title compound.

1. customwas hydrogenated under a H2 atm for 14 hours
2. filtrationfiltered through a celite pad
3. concentrationThe filtrate was concentrated
4. custompurified by flash chromatography on a silica gel column (chloroform:methanol, 92.5:7.5 spiked with acetic acid)