Sodium Hydroxide → 3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole

HRID 448546Notes

Reaction equation

HRID 448546 reaction equation
Cl.[F:2][C:3]1[CH:17]=[CH:16][C:6]2[C:7]([CH:10]3[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]3)=[N:8][O:9][C:5]=2[CH:4]=1.[OH-].[Na+]>O>[F:2][C:3]1[CH:17]=[CH:16][C:6]2[C:7]([CH:10]3[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]3)=[N:8][O:9][C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11334359R-56109 hydrochloride

Product 1

HCID 8494213-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To the suspension of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride (25 grams) (formula-6) dissolved in water (100 ml), added aqueous sodium hydroxide (4.8 grams in 20 ml water). Stirred for 20 min and filtered the precipitated solid. Washed the solid with cold water and dried to obtain the title compound.

Workup

  1. filtrationfiltered the precipitated solid
  2. washWashed the solid with cold water
  3. customdried

Sources & evidence

ORD record
ord-56600143162a46be92abf9c9c686668e
Source dataset
uspto-grants-2013_07
Patent number
US08481729B2

Reaction notes

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