HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | R-56109 hydrochloride | HCID 11334359 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole | HCID 849421 | — |
Reaction Steps
To the suspension of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride (25 grams) (formula-6) dissolved in water (100 ml), added aqueous sodium hydroxide (4.8 grams in 20 ml water). Stirred for 20 min and filtered the precipitated solid. Washed the solid with cold water and dried to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481729B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-56600143162a46be92abf9c9c686668e |
| Source note | uspto-grants-2013_07 |