Sodium Hydroxide → 3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole

HRID 448547Notes

Reaction equation

HRID 448547 reaction equation
Cl.[F:2][C:3]1[CH:17]=[CH:16][C:6]2[C:7]([CH:10]3[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]3)=[N:8][O:9][C:5]=2[CH:4]=1.[OH-].[Na+]>O>[F:2][C:3]1[CH:17]=[CH:16][C:6]2[C:7]([CH:10]3[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]3)=[N:8][O:9][C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11334359R-56109 hydrochloride

Product 1

HCID 8494213-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To the suspension of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride (formula-6) (25 grams) dissolved in water (100 ml), added aqueous sodium hydroxide (4.8 g in 20 ml water). Stirred for 20 min and extracted with dichloromethane. Washed the organic layer with water, distilled off the solvent under reduced pressure to obtain the title compound.

Workup

  1. extractionextracted with dichloromethane
  2. washWashed the organic layer with water
  3. distillationdistilled off the solvent under reduced pressure

Sources & evidence

ORD record
ord-985ddfdb5d364ae6a091493fe22f6a4a
Source dataset
uspto-grants-2013_07
Patent number
US08481729B2

Reaction notes

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