HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | R-56109 hydrochloride | HCID 11334359 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole | HCID 849421 | — |
Reaction Steps
To the suspension of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride (formula-6) (25 grams) dissolved in water (100 ml), added aqueous sodium hydroxide (4.8 g in 20 ml water). Stirred for 20 min and extracted with dichloromethane. Washed the organic layer with water, distilled off the solvent under reduced pressure to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481729B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-985ddfdb5d364ae6a091493fe22f6a4a |
| Source note | uspto-grants-2013_07 |