反应详情

温度

80 °C

5-Bromoindoline (60 mg, 0.3 mmol) and potassium tert-butoxide (0.1 g, 3 eq) were stirred for 5 minutes in dioxane (1 mL). 3a (0.1 g, 1.05 eq) was added and the mixture was stirred at 80° C. for 72 h. The solvent was removed under vacuum and the residue was dissolved in THF and purified by preparative HPLC to give 3b.

1. customThe solvent was removed under vacuum
2. dissolutionthe residue was dissolved in THF
3. custompurified by preparative HPLC