HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 448559Generated: October 27, 2026
5-Bromoindoline → 4-[6-(5-Bromo-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/448559
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Bromoindoline | HCID 3411566 | — |
| Reactant | tert-Butyl 4-[(6-chloropyrimidin-4-yl)oxy]piperidine-1-carboxylate | HCID 21906116 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[6-(5-Bromo-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid tert-butyl ester | HCID 66894195 | — |
Reaction Steps
5-Bromoindoline (60 mg, 0.3 mmol) and potassium tert-butoxide (0.1 g, 3 eq) were stirred for 5 minutes in dioxane (1 mL). 3a (0.1 g, 1.05 eq) was added and the mixture was stirred at 80° C. for 72 h. The solvent was removed under vacuum and the residue was dissolved in THF and purified by preparative HPLC to give 3b.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08481731B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-07e99a8729f849cca13a40a5dd12ace7 |
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| Source note | uspto-grants-2013_07 |
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