HRID44856
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 80 °C
PROCEDURE
实验过程
(R)-8-cyclobutyl-7-ethyl-2-(1H-imidazol-1-yl)-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 111, 0.14 g, 0.448 mmol) was dissolved in 2 mL of THF and NIS (0.20 g, 0.896 mmol) was added. The solution was stirred at 80° C. for 6 hours after which the solution was concentrated and purified by preparative HPLC to give the title compound (276 mg). LCMS: 410.2 m/z (M+H)+; ret. Time: 3.81 (Analytical Method A).
WORKUP
后处理
- concentrationwas concentrated
- custompurified by preparative HPLC