HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → [6-(5-Methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yl]-piperidin-4-yl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-[6-(5-Methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-ylamino]-piperidine-1-carboxylic acid tert-butyl ester | HCID 58074125 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [6-(5-Methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yl]-piperidin-4-yl-amine | HCID 66894566 | 17% |
Reaction Steps
The solution of 6b obtained above was diluted with 5 mL of DCM and trifluoroacetic acid (5 mL, 60 eq) was added. The reaction mixture was stirred at room temperature for 2 h then concentrated under a stream of nitrogen overnight and purified on preparative HPLC to afford 104 mg (17%) of 6c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481731B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-ecbd6cef39034ec8811f4a4b7a3e07b0 |
| Source note | uspto-grants-2013_07 |