反应详情

The solution of 6b obtained above was diluted with 5 mL of DCM and trifluoroacetic acid (5 mL, 60 eq) was added. The reaction mixture was stirred at room temperature for 2 h then concentrated under a stream of nitrogen overnight and purified on preparative HPLC to afford 104 mg (17%) of 6c.

1. additionwas added
2. concentrationthen concentrated under a stream of nitrogen overnight
3. custompurified on preparative HPLC