HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 70837807, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-Chloroethyl chloroformate | HCID 521305 | — |
| Reactant | (1-Benzyl-piperidin-4-yl)-[6-(5-methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yl]-methyl-amine | HCID 86761923 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 70837807 | HCID 70837807 | 15% |
Reaction Steps
7c was taken up in DCM (2 mL). Diisopropylethylamine (0.6 mL, 11 eq) and 1-chloroethyl chloroformate (0.2 mL, 5.7 eq) were added. The reaction mixture was stirred at room temperature for 22 h. The solvent was then evaporated under a stream of nitrogen and the residue was dissolved in methanol and heated at 50° C. for 3 h. The solvent was removed under a stream of nitrogen and the residue was purified by preparative HPLC to give 25 mg (15%) of 7d.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481731B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-1fa52065bbc347d58b5b026088b5c88a |
| Source note | uspto-grants-2013_07 |