反应详情

7c was taken up in DCM (2 mL). Diisopropylethylamine (0.6 mL, 11 eq) and 1-chloroethyl chloroformate (0.2 mL, 5.7 eq) were added. The reaction mixture was stirred at room temperature for 22 h. The solvent was then evaporated under a stream of nitrogen and the residue was dissolved in methanol and heated at 50° C. for 3 h. The solvent was removed under a stream of nitrogen and the residue was purified by preparative HPLC to give 25 mg (15%) of 7d.

1. customThe solvent was then evaporated under a stream of nitrogen
2. dissolutionthe residue was dissolved in methanol
3. temperatureheated at 50° C. for 3 h
4. customThe solvent was removed under a stream of nitrogen
5. customthe residue was purified by preparative HPLC