反应详情

To a solution of 18a (3.26 g, 11.37 mmol) in 10 mL of DCM, was added TFA (5 mL, 64.9 mmol). The mixture was stirred at room temperature for 2 h and the solvent were evaporated. The residue was dissolved in DCM and a saturated solution of NaHCO3 and 1N NaOH were added until pH was 8. The layers were separated and the aqueous layer was extracted with 3:1 DCM:IPA (3×40 mL). The organic extracts were combined, dried, filtered and evaporated to afford 1.89 g (89%) of 18b.

1. customthe solvent were evaporated
2. dissolutionThe residue was dissolved in DCM
3. additiona saturated solution of NaHCO3 and 1N NaOH were added until pH was 8
4. customThe layers were separated
5. extractionthe aqueous layer was extracted with 3:1 DCM
6. customdried
7. filtrationfiltered
8. customevaporated