Trifluoroacetic acid → HCID 58116602, compound

HRID 448587Notes

Reaction equation

HRID 448587 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[N:20]=[CH:19][N:18]=[C:17]([N:21]3[C:29]4[C:24](=[CH:25][C:26]([C:30]([OH:32])=[O:31])=[CH:27][CH:28]=4)[CH2:23][CH2:22]3)[CH:16]=2)[CH2:10][CH2:9]1)=[O:7])(C)([CH3:3])[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[N:20]=[CH:19][N:18]=[C:17]([N:21]3[C:29]4[C:24](=[CH:25][C:26]([C:30]([OH:32])=[O:31])=[CH:27][CH:28]=4)[CH2:23][CH2:22]3)[CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58074068HCID 58074068, compound

Product 1

HCID 58116602HCID 58116602, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 19b (65 mg, 0.37 mmol) in 1.5 mL of DCM, was added TFA (1.5 mL, 19.5 mmol) and the reaction was stirred at room temperature for 2 h. The mixture was concentrated to give 19c.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-faa4c03d5723426b915dcd11de6265ec
Source dataset
uspto-grants-2013_07
Patent number
US08481731B2

Reaction notes

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