Trifluoroacetic acid → HCID 49848660, compound

HRID 448595Notes

Reaction equation

HRID 448595 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([O:12][C:13]([N:15]2[CH2:20][CH2:19][CH:18]([O:21][C:22]3[CH:27]=[C:26]([N:28]4[C:36]5[C:31](=[CH:32][C:33]([S:37]([CH3:40])(=[O:39])=[O:38])=[CH:34][CH:35]=5)[CH2:30][CH2:29]4)[N:25]=[CH:24][N:23]=3)[CH2:17][CH2:16]2)=[O:14])[CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:8]1[CH2:11][CH:10]([O:12][C:13]([N:15]2[CH2:16][CH2:17][CH:18]([O:21][C:22]3[CH:27]=[C:26]([N:28]4[C:36]5[C:31](=[CH:32][C:33]([S:37]([CH3:40])(=[O:39])=[O:38])=[CH:34][CH:35]=5)[CH2:30][CH2:29]4)[N:25]=[CH:24][N:23]=3)[CH2:19][CH2:20]2)=[O:14])[CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66892955HCID 66892955, compound

Product 1

HCID 49848660HCID 49848660, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Half of 22a was dissolved in 2.5 mL of DCM and 2.5 mL of TFA was added. The mixture was stirred at room temperature for 2 h then evaporated. The crude material was purified by preparative HPLC to afford 22-1, LCMS 474.1 (MH+).

Workup

  1. customthen evaporated
  2. customThe crude material was purified by preparative HPLC
  3. customto afford 22-1, LCMS 474.1 (MH+)

Sources & evidence

ORD record
ord-76b835bc6ea549989e2dbff474ddd59e
Source dataset
uspto-grants-2013_07
Patent number
US08481731B2

Reaction notes

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