反应详情

A mixture of product from Step B (90 mg, 0.3 mmol) in aqueous NaOH (2N, 9 mL) was heated at reflux temperature for 5 h, then neutralized at 0° C. with 2 N aqueous HCl and evaporated to dryness. Purification on a silica gel column with CH2Cl2/MeOH, 5/1 as eluent afforded the title compound as a white solid (70 mg).

1. temperaturewas heated
2. temperatureat reflux temperature for 5 h
3. customevaporated to dryness
4. customPurification on a silica gel column with CH2Cl2/MeOH, 5/1 as eluent