2-(3-Bromophenyl)-1H-imidazole → (R)-2-(2-(3-bromophenyl)-1H-imidazol-1-yl)-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one

HRID 44879Notes

Reaction equation

HRID 44879 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]([CH3:18])[CH3:17])[C:4]=2[N:3]=1.[Br:19][C:20]1[CH:21]=[C:22]([C:26]2[NH:27][CH:28]=[CH:29][N:30]=2)[CH:23]=[CH:24][CH:25]=1>>[Br:19][C:20]1[CH:21]=[C:22]([C:26]2[N:30]([C:2]3[N:11]=[CH:10][C:9]4[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]([CH3:18])[CH3:17])[C:4]=4[N:3]=3)[CH:29]=[CH:28][N:27]=2)[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 529838842-(3-Bromophenyl)-1H-imidazoleHCID 58405561(R)-2-Chloro-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropyrimido[4,5-b]pyrazine

Product 1

HCID 58405672(R)-2-(2-(3-bromophenyl)-1H-imidazol-1-yl)-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one

Procedure

The title compound was prepared similarly to the methods described in Example 26, with Intermediate C instead of Intermediate B and with 2-(3-bromophenyl)-1H-imidazole instead of 2-phenyl-1H-imidazole. LCMS: 455.0 m/z (M+H)+; ret. Time: 4.34 min (Analytical Method D).

Sources & evidence

ORD record
ord-7342c4922c9a4cf88d354e46cf2a3d9d
Source dataset
uspto-grants-2013_09
Patent number
US08541418B2

Reaction notes

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