反应详情

A solution of 2-methylaminophenol (0.74 g, 6.0 mmol), Triton B (60 μL, 40% in water) and acrylonitrile (4.0 mL, 60 mmol) was refluxed for 16 hrs. The mixture was diluted with ethyl acetate. The organic layer was then washed with water and brine, and was dried over MgSO4. After filtration and concentration, the residue was purified via silica gel flash column chromatography eluting with 20% ethyl acetate in hexane to give 3-(2-methylamino-phenoxy)-propionitrile (4.0 g) as a brown oil. [M+H]+177.1; tR=0.715 min (method 1).

1. washThe organic layer was then washed with water and brine
2. dry with materialwas dried over MgSO4
3. filtrationAfter filtration and concentration
4. customthe residue was purified via silica gel flash column chromatography
5. washeluting with 20% ethyl acetate in hexane