Indole → HCID 58405790, compound

HRID 44897Notes

Reaction equation

HRID 44897 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[C:4]=2[N:3]=1.[NH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22]1>>[CH:16]1([N:5]2[C:4]3[N:3]=[C:2]([N:21]4[C:29]5[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=5)[CH:23]=[CH:22]4)[N:11]=[CH:10][C:9]=3[N:8]([CH3:12])[C:7](=[O:13])[C@H:6]2[CH2:14][CH3:15])[CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 798IndoleHCID 24820413(R)-2-Chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one

Product 1

HCID 58405790HCID 58405790, compound

Procedure

The title compound was prepared similarly to the methods described in Example 77, with Intermediate B instead of Intermediate C and with indole instead of 2-phenyl-1H-imidazole. LCMS: 376.2 m/z (M+H)+; ret. Time: 9.10 min (Analytical Method A).

Sources & evidence

ORD record
ord-e449ac4e97924c6d904b7f0abce4cac4
Source dataset
uspto-grants-2013_09
Patent number
US08541418B2

Reaction notes

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