O-Cresol → HCID 57960987, compound

HRID 449044Notes

Reaction equation

HRID 449044 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH:18]3[CH2:21][CH2:20][CH2:19]3)[N:11]3[CH:16]=[CH:15][N:14]=[C:13]([NH2:17])[C:12]=23)=[CH:4][C:3]=1[F:22].[CH3:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[OH:30]>>[CH:18]1([C:10]2[N:11]3[CH:16]=[CH:15][N:14]=[C:13]([NH2:17])[C:12]3=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([O:30][C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[CH3:23])=[C:3]([F:22])[CH:4]=3)[N:9]=2)[CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 335O-CresolHCID 66915652HCID 66915652, compound

Product 1

HCID 57960987HCID 57960987, compound

Procedure

Prepared according to a procedure analogous to that described for synthesis of Example 171, except using 1-(4-bromo-3-fluoro-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine and 2-methyl-phenol.

Workup

  1. customPrepared
  2. customthat described for synthesis of Example 171

Sources & evidence

ORD record
ord-1bd8f007f7be49ce824e24148554811b
Source dataset
uspto-grants-2013_07
Patent number
US08481733B2

Reaction notes

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