反应详情

Into a 100 mL round bottom flask was added 4-bromophenol (2.07 g, 12.0 mmol), 2-nitrophenylboronic acid (1.00 g, 5.99 mmol), cupric acetate (1.4 g, 7.70 mmol) and DCM (50 mL). TEA (4.0 mL, 29.0 mmol) was then added followed by 4 A° molecular sieves and the reaction mixture was stirred at rt for 48 h. Reaction mixture was then filtered through celite. The filtrate was concentrated in vacuo to give a residue which was purified by silica gel chromatography, eluting with 5% EtOAc in hexane.

1. customReaction mixture
2. filtrationwas then filtered through celite
3. concentrationThe filtrate was concentrated in vacuo
4. customto give a residue which
5. customwas purified by silica gel chromatography
6. washeluting with 5% EtOAc in hexane