反应详情

3-Bromophenol (0.870 g, 5.00 mmol), (2-chloro-ethyl)-dimethylamine hydrochloride (0.792 g, 5.50 mmol) and Cs2CO3 (8 g, 25 mmol) were combined in DMF (20 mL) and the mixture was heated at reflux over night. H2O (20 mL) was added and the mixture was extracted with EtOAc, then washed with 2N NaOH and brine. The organic layers were combined, dried over Na2SO and concentrated to a brown oil which was then purified by flash chromatography (eluent: 20% EtOAc in hexanes).

1. temperaturethe mixture was heated
2. temperatureat reflux over night
3. extractionthe mixture was extracted with EtOAc
4. washwashed with 2N NaOH and brine
5. dry with materialdried over Na2SO
6. concentrationconcentrated to a brown oil which
7. customwas then purified by flash chromatography (eluent: 20% EtOAc in hexanes)