HCID 22645922, compound → 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride

HRID 449180Notes

Reaction equation

HRID 449180 reaction equation
[ClH:1].[F:2][C:3]1([F:17])[C:7]([F:9])([F:8])[CH2:6][N:5](CC2C=CC=CC=2)[CH2:4]1.[H][H]>[Pd].C(O)C>[ClH:1].[F:2][C:3]1([F:17])[C:7]([F:9])([F:8])[CH2:6][NH:5][CH2:4]1

Participants

5

Reactant 2

HCID 22645922HCID 22645922, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 226459203,3,4,4-Tetrafluoropyrrolidine HydrochlorideYield 98%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

An ethanol solution of 16.9 g of the residue 3,3,4,4-tetrafluoro-1-benzyl-pyrrolidine hydrochloride and 1.8 g of 10% Pd/C was stirred at room temperature for 3 hours in a manner of contacting hydrogen gas under ordinary pressure. After filtration, the solvent was distilled off to provide 11 g (yield: 98%) of desired 3,3,4,4-tetrafluoro-pyrrolidine hydrochloride.

Workup

  1. filtrationAfter filtration
  2. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-fe29a1d4e88448a695dcedbcf016f3e5
Source dataset
uspto-grants-2013_07
Patent number
US08481774B2

Reaction notes

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