4-(Methylcarbamoyl)benzeneboronic acid → 4-(6-fluoropyridin-3-yl)-N-methylbenzamide

HRID 449333Notes

Reaction equation

HRID 449333 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:8])=[N:6][CH:7]=1.[CH3:9][NH:10][C:11]([C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][CH:14]=1)=[O:12]>>[F:8][C:5]1[N:6]=[CH:7][C:2]([C:16]2[CH:17]=[CH:18][C:13]([C:11]([NH:10][CH3:9])=[O:12])=[CH:14][CH:15]=2)=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 27735264-(Methylcarbamoyl)benzeneboronic acidHCID 27831685-Bromo-2-fluoropyridine

Product 1

HCID 594966104-(6-fluoropyridin-3-yl)-N-methylbenzamide

Procedure

This compound was prepared from 5-bromo-2-fluoropyridine and {4-[(methylamino)carbonyl]phenyl}boronic acid using procedures analogous to those for Example 18, step 1. Analytic LCMS (M+H)+: m/z=231.1.

Sources & evidence

ORD record
ord-34f54c66e3a9478eab1f60f71a582125
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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