Hydrochloric Acid → Hydrochloric Acid

HRID 449357Notes

Reaction equation

HRID 449357 reaction equation
[ClH:1].C(OC(=O)[NH:8][CH:9]1[CH2:14][CH2:13][CH:12]([C:15]([N:17]([CH3:19])[CH3:18])=[O:16])[CH2:11][CH2:10]1)(C)(C)C>O1CCOCC1.CO>[NH2:8][CH:9]1[CH2:10][CH2:11][CH:12]([C:15]([N:17]([CH3:19])[CH3:18])=[O:16])[CH2:13][CH2:14]1.[ClH:1]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 69309396Tert-butyl{4-[(dimethylamino)carbonyl]cyclohexyl}carbamate

Product 2

HCID 313Hydrochloric AcidHCID 577096314-amino-N,N-dimethylcyclohexane-1-carboxamide

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

2 mL of 4 N HCl in 1,4-dioxane was added to a solution of tert-butyl{4-[(dimethylamino)carbonyl]cyclohexyl}carbamate (0.20 g, 0.74 mmol) in methanol (1.0 mL). The reaction mixture was stirred at r.t. for 2 h. The volatiles were removed under reduced pressure to afford the desired product as an HCl salt.

Workup

  1. customThe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-7b495394aa954bf4a14138b139186545
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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