1246210-02-5 → HCID 49779588, compound

HRID 449373Notes

Reaction equation

HRID 449373 reaction equation
[F:1][C:2]1([F:11])[CH2:7][CH2:6][CH:5]([N:8]=[C:9]=[O:10])[CH2:4][CH2:3]1.Cl.[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([C:20]2[CH:25]=[C:24]([C:26]3[CH:35]=[C:34]4[C:29]([CH2:30][CH2:31][NH:32][CH2:33]4)=[CH:28][CH:27]=3)[N:23]=[C:22]([NH2:36])[N:21]=2)[CH2:16][CH2:15]1>>[NH2:36][C:22]1[N:23]=[C:24]([C:26]2[CH:35]=[C:34]3[C:29]([CH2:30][CH2:31][N:32]([C:9]([NH:8][CH:5]4[CH2:4][CH2:3][C:2]([F:11])([F:1])[CH2:7][CH2:6]4)=[O:10])[CH2:33]3)=[CH:28][CH:27]=2)[CH:25]=[C:20]([N:17]2[CH2:16][CH2:15][N:14]([CH3:13])[CH2:19][CH2:18]2)[N:21]=1

Participants

3

Reactant 2

HCID 594965391246210-02-5HCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 49779588HCID 49779588, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 5 starting from 1,1-difluoro-4-isocyanatocyclohexane and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=486.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-61869f62c1094ea3b85dea4d844be750
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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