HCID 19985489, compound → HCID 59496633, compound

HRID 449374Notes

Reaction equation

HRID 449374 reaction equation
[N:1]([CH:4]1[CH2:9][CH2:8][CH:7]([C:10]([F:13])([F:12])[F:11])[CH2:6][CH2:5]1)=[C:2]=[O:3].Cl.[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:22]2[CH:27]=[C:26]([C:28]3[CH:37]=[C:36]4[C:31]([CH2:32][CH2:33][NH:34][CH2:35]4)=[CH:30][CH:29]=3)[N:25]=[C:24]([NH2:38])[N:23]=2)[CH2:18][CH2:17]1>>[NH2:38][C:24]1[N:25]=[C:26]([C:28]2[CH:37]=[C:36]3[C:31]([CH2:32][CH2:33][N:34]([C:2]([NH:1][CH:4]4[CH2:5][CH2:6][CH:7]([C:10]([F:11])([F:12])[F:13])[CH2:8][CH2:9]4)=[O:3])[CH2:35]3)=[CH:30][CH:29]=2)[CH:27]=[C:22]([N:19]2[CH2:18][CH2:17][N:16]([CH3:15])[CH2:21][CH2:20]2)[N:23]=1

Participants

3

Reactant 2

HCID 19985489HCID 19985489, compoundHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 59496633HCID 59496633, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 5 starting from 1-isocyanato-4-(trifluoromethyl)cyclohexane, and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=518.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-91bfb64053c6465193cab521445f4fd9
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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